EFFECT OF MACROPHAGE COLONY-STIMULATING FACTOR ON THE FUNCTION OF RESIDENT PERITONEAL MACROPHAGES
スポンサーリンク
概要
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Resident peritoneal cells of monocyte/macrophage lineage were collected by lavage of mice and incubated in vitro for 1-3 d in a culture medium containing various concentrations of macrophage colony-stimulating factor (M-CSF). Stimulation of the cells by zymosan showed that the potency of producing luminol-dependent chemiluminescence had been markedly increased in the CSF-treated cells, indicating increased generation of active oxygen species in these cells. There was an optimal concentration of M-CSF for the enhancement, and the potency of the cells was notably decreased by an overdose of M-CSF. The result was interpreted as being due to the down-regulation of M-CSF receptor.
- 公益社団法人日本薬学会の論文
著者
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Kanegasaki Shiro
National Institute Of Radiological Sciences:denki Kagaku Kogyo Co.:institute Of Medical Sciences Uni
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Sakai Nobuo
National Institute Of Radiological Sciences:denki Kagaku Kogyo Co.:institute Of Medical Sciences Uni
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Shikita Mikio
National Institute Of Radiological Sciences
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Shikita Mikio
National Institute Of Radiological Sciences:denki Kagaku Kogyo Co.:institute Of Medical Sciences Uni
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Tomita Toshio
National Institute Of Radiological Sciences:denki Kagaku Kogyo Co.:institute Of Medical Sciences Uni
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Tsuneoka Kazuko
National Institute Of Radiological Sciences
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Tsuneoka Kazuko
National Institute Of Radiological Sciences:denki Kagaku Kogyo Co.:institute Of Medical Sciences Uni
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Kanada Tomoko
National Institute Of Radiological Sciences:denki Kagaku Kogyo Co.:institute Of Medical Sciences Uni
関連論文
- Recovery of Number and Radiosensitivity of Myeloid Stem Cells (CFU-C) in the Sublethally X-Irradiated Mice
- EFFECT OF MACROPHAGE COLONY-STIMULATING FACTOR ON THE FUNCTION OF RESIDENT PERITONEAL MACROPHAGES
- EFFECT OF VARIOUS IMMUNOMODULATORS ON THE PRODUCTION OF GRANULOCYTE/MACROPHAGE COLONY-STIMULATING FACTOR (GM-CSF) IN MOUSE SPLEEN CELL CULTURES
- EFFECT OF VARIOUS THERAPEUTIC AGENTS ON LEUKOCYTES IN VIVO AND IN VITRO : COMPETITION BETWEEN THE CYTOTOXIC DRUGS AND COLONY STIMULATING FACTOR (CSF) IN THE ACTION ON THE PROLIFERATION OF MYELOID STEM CELLS (CFU-C)
- EFFECT OF VARIOUS KINDS OF DRUGS IN VITRO ON THE PROLIFERATION OF LEUKOPOIETIC STEM CELLS (CFU-C)
- Radiosensitivity of Mouse Myeloid Stem Cells in Culture after Stimulation by Macrophage Colony-Stimulating Factor
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