Triiodothyronine Rapidly Stimulates Mitochondrial Respiration in Isolated Hepatocytes

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概要

• 論文の詳細を見る

• Isolated hepatocytes from euthyroid or hypothyroid (thyroidectomized) rats showed a 20 to 30% stimulation of respiratory activity when treated with triiodothyronine (T_3). Maximal stimulation was obtained in the presence of the uncoupler carbonylcyanide m-chlorophenyl-hydrazone (CCCP) suggesting a direct effect on the respiratory chain. Physiological concentrations of T_3 (10^<-11>-10^<-9>) induced maximal stimulation after a short incubation (75% of maximum in 3 min) and the effect persisted for over 1 h of incubation. Mitochondria, rapidly isolated from T_3-treated hepatocytes, retained stimulated respiratory activity in both coupled and uncoupled states. These results are consistent with the hypothesis that the mitochondrion is a primary target for thyroid hormones, and the present system appears to be suitable for the systematic investigation of these effects.

• 公益社団法人日本薬学会の論文
• 1986-10-25

著者

• 樋口 富彦

  Faculty Of Pharmaceutical Sciences University Of Tokushima

• 樋口 富彦

  Department of Pathology and Laboratory Medicine, Hahnemann University, School of Medicine

• ROTTENBERG HAGAI

  Department of Pathology and Laboratory Medicine, Hahnemann University, School of Medicine

• Rottenberg Hagai

  Department Of Pathology And Laboratory Medicine Hahnemann University School Of Medicine

関連論文

• Triiodothyronine Rapidly Stimulates Mitochondrial Respiration in Isolated Hepatocytes
• Energization of Mitochondrial Inner Membranes by L-Malate under Anaerobic Condition is Driven by Energy Derived at Site I of Phosphorylation

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