Identity of the Synthetic Carbocylic Analog of Adenosine and Aristeromycin

概要

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Comparisons of aristeromycin and the synthetic carbocyclic analog (C-Ado) of adenosine by several methods have been made because of anomalous results relating to aristeromycin that have appeared in the literature. Aristeromycin and C-Ado demonstrated the same behavior in four thin-layer chromatography and three high-pressure liquid chromatography solvent systems. Proton (100 MHz) and carbon-13 (25 MHz) nuclear magnetic resonance spectra of the two substances, determined under the same experimental conditions, are identical. Previously, comparisons of certain data had supported the identity of aristeromycin and C-Ado ; the data presented here show unequivocally that the synthetic and natural forms of the carbocyclic analog of adenosine are identical.
公益社団法人日本薬学会の論文
1980-10-25