Spectrophotometric and Fluorimetric Determination of Hexamine in Pure Form and Its Pharmaceutical Formulation(Biopharmacy)

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概要

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• Ethyl acetoacetate and methyl acetoacetate have been tested for the determination of hiprex (methenamine hippurate). Both the esters react with hexamine and hiprex forming fluorescent yellow Hantzsch esters. The products show absorption maximum at 370 nm and a fluorescence emission maximum at 465 nm in aqueous n-propanol. Important parameters such as pH, temperature, mole ratio and time of reaction have been optimized. The co-efficient of variation for inter and intra-day precisions were less than 1%. The chromogens show linearity in the concentration ranges of 2.0-35.0μg ml^<-1> and 0.6-40.0μg ml^<-1> for the spectrometric and fluorimetric determinations of hiprex, respectively.

• 公益社団法人日本薬学会の論文
• 2003-08-01

著者

• Perumal Paramasivam

  Organic Chemistry Division Central Leather Research Institute

• BALASUBRAMANIAN Maruthamuthu

  Organic Chemistry Division, Central Leather Research Institute

• THENNARASU Sathiah

  Organic Chemistry Division, Central Leather Research Institute

• SUDHAKARAN Thankiah

  Jonaki, BRIT, CCMB-Campus

• Sudhakaran Thankiah

  Jonaki Brit Ccmb-campus

• Thennarasu Sathiah

  Organic Chemistry Division Central Leather Research Institute

• Balasubramanian Maruthamuthu

  Organic Chemistry Division Central Leather Research Institute

関連論文

• Spectrophotometric and Fluorimetric Determination of Hexamine in Pure Form and Its Pharmaceutical Formulation(Biopharmacy)

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