In Vitro and in Vivo Correlation for Controlled-Release Formulation of d-Chlorpheniramine Maleate

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概要

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• Four commercial controlled-release tablets of d-chlorpheniramine maleate, which showed various drug release properties, were administered to beagle dogs, and the correlation between in vitro drug release and in vivo absorption was studied. The mean in vivo absorption amount-time profile for each product showed good accordance with the in vitro drug release profile until 2-3 h after administration. However, absorption of the drug in dogs terminated at about 3 h. This short absorption time may be due to a short intestinal residence time for these dosage forms in the dog. In the present study, the deconvolution method was proved to be useful for in vitro/in vivo comparison, which clarified the in vivo absorption of controlled-release dosage forms having various release profiles.

• 公益社団法人日本薬学会の論文

著者

• Aoyagi Nobuo

  Drug Division National Institute Of Hygienic Sciences

• Takeda Yasushi

  Drug Division National Institute Of Hygienic Sciences

• KATORI Noriko

  Drug Division, National Institute of Hygienic Sciences

• OKUDAIRA Kazuho

  Drug Division, National Institute of Hygienic Sciences

• Uchiyama Mitsuru

  Drug Division, National Institute of Hygienic Sciences

• Uchiyama Mitsuru

  Drug Division National Institute Of Hygienic Sciences

• Okudaira Kazuho

  Drug Division National Institute Of Hygienic Sciences

• Katori Noriko

  Drug Division National Institute Of Hygienic Sciences

関連論文

• Effect of Quinidine on the Hepatic Uptake of Digoxin in Guinea Pigs
• THE EFFECT OF BASIC DRUGS ON THE HEPATIC TRANSPORT OF CARDIAC GLYCOSIDES IN RATS
• In Vitro and in Vivo Correlation for Controlled-Release Formulation of d-Chlorpheniramine Maleate

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