Studies on Carcinostatic Substances. XXI. Effect of Mercapto Compounds on Experimental Leucopenia of Rat induced by Nitrogen Mustard N-Oxide

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概要

• 論文の詳細を見る

• Mercapto compounds were tested as to their chemical reactivity with nitrogen mustard (HN_2) and its N-oxide (HN_2-O) in vitro, and as to their preventive action in vivo against rat leucopenia induced by the same agents. Of these compounds, L-cysteine alone was found to show remarkable activity in vivo, while D-cysteine and L-cysteine methyl ester were proved to be only slightly effective. Administration of L-cysteine 30 min. after HN_2-O injection prevented to some extent the leucopenia of Yoshida sarcoma rats without being deprived of its anti-tumor effect.

• 公益社団法人日本薬学会の論文
• 1959-12-20

著者

• 松井 英一

  Iatrochemical Institute of Pharmacological Research Foundation

関連論文

• Studies on Carcinostatic Substances. XXIV. Preparation of Diphenylphosphoric Acid Esters of N-Methyl-and N-Phenyl-bis(2-hydroxyethyl)amine and their Alkylating Activity.
• Studies on Carcinostatic Substances. XXIII. Correlation between Anti-tumor and leucopenia-inducing Effects of Alkylating Agents
• Studies on Carcinostatic substances. XXV. Effect of dl-Octadecyl α-Glyceryl Ether on Experimental Leucopenia of Rat induced by Nitrogen Mustard N-Oxide.
• Studies on Carcinostatic Substances. XXI. Effect of Mercapto Compounds on Experimental Leucopenia of Rat induced by Nitrogen Mustard N-Oxide

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