Synthesis and Biological Activity of 5'-Aminobenzoxazinorifamycin Derivatives

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概要

• 論文の詳細を見る

• Benzoxazinorifamycin reacted with various secondary amines to yield various 5'-substituted aminobenzoxazinorifamycin derivatives. The derivatives exhibited potent acitvities against gram-positive bacteria and mycobacteria. The antimicrobial activities of these compounds against Mycobacterium tuberculosis and Mycobacterium intracellulare were superior to those of rifampicin. Some of these compounds showed good plasma levels after oral administration in rats.

• 社団法人日本薬学会の論文
• 1992-10-25

著者

• 日高 隆義

  Biochemical Research Laboratories Kaneka Corporation

• 渡辺 清

  Biochemical Research Laboratories Kaneka Corporation

• 山根 毅彦

  Biochemical Research Laboratories, Kaneka Corporation

• 橋爪 卓士

  Biochemical Research Laboratories, Kaneka Corporation

• 山下 勝治

  Biochemical Research Laboratories, Kaneka Corporation

• 細江 和典

  Biochemical Research Laboratories, Kaneka Corporation

• 川原田 肇

  Biochemical Research Laboratories, Kaneka Corporation

• 工藤 祐是

  Research Institute of Japan Anti-Tuberculosis Association

• 川原田 肇

  Biochemical Research Laboratories Kaneka Corporation

• 山下 勝治

  Biochemical Research Laboratories Kaneka Corporation

• 細江 和典

  Biochemical Research Laboratories Kaneka Corporation

• 山根 毅彦

  Biochemical Research Laboratories Kaneka Corporation

• 橋爪 卓士

  Biochemical Research Laboratories Kaneka Corporation

• 渡辺 清

  Biochemical Research Laboratories Kanegafuchi Chemical Industry Co. Ltd.

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