Evidence of Chemical Instability of Phospholipids in Liposomes

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概要

• 論文の詳細を見る

• Chemical instability of liposomes containing dipalmitoylphosphatidylcholine (DPPC), distearoylphosphatidylcholine (DSPC) and soybean phosphatidylcholine (4 : 4 : 2,w/w) was examined.Various methods were employed to evaluate the phospholipids degradation : peroxidation index, malondialdehyde determination, reverse-phase high-performance liquid chromatography of DSPC and DPPC, thin layer chromatography of lysophosphatides and gas chromatography-mass spectrometry of free and total fatty acids. Formation of palmitoyllysophosphatidylcholine and stearoyllysophosphatidylcholine was detected within one month during storage.

• 公益社団法人日本薬学会の論文
• 1988-11-25

著者

• Pradeau Dominique

  Laboratoire De Controle De Qualite Pharmacie Centrale Des Hopitaux De Paris

• Prognon Patrice

  Laboratoire De Controle De Qualite Pharmacie Centrale Des Hopitaux De Paris

• Prognon Patrice

  Laboratoire De Chimie Analytique Faculte Des Sciences Pharmaceutiques Et Biologiques De Paris Sud

• Postaire E

  Laboratoire De Controle De Qualite Pharmacie Centrale Des Hopitaux De Paris

• Lize Jean

  Laboratoire De Controle De Qualite Pharmacie Centrale Des Hopitaux De Paris

• PIRAUBE CHRISTINE

  Mise au Point Galenique

• POSTAIRE ERIC

  Laboratoire de Controle de Qualite, Pharmacie Centrale des Hopitaux de Paris

• Piraube Christine

  Mise Au Point Galenique:pharmacie Centrale Des Hopitaux De Paris

関連論文

• Evidence of Chemical Instability of Phospholipids in Liposomes
• Solvatochromic Study of the Separation of Glycyl-Leucyl-Phenylalanine and Some Homologous by Reversed-Phase High-Performance Liquid Chromatography

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