制癌効果を有するアミノグリコールメタンスルフォン酸誘導体No.838およびNo.864の末梢血白血球に対する影響

概要

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Leukopenia-inducing action of N-methyl-bis(3-mesyloxypropyl)amine hydrochloride (No.838) and bis(3-mesyloxypropyl)amine hydrochloride (No.864) was discussed. In spite of their similarity in chemical structure, the two compounds have different antitumor spectrum and different affinity to hematopoietic tissues. Leukopenia induced by No.838 was far more severe than that by No.864,which was found to be protected by 2-mercaptopropionylglycine to some extent without affecting its antitumor activity.
公益社団法人日本薬学会の論文
1970-12-25