1-Methyl-3-「di(2-thienyl)methylene」piperidine Citrateの代謝に関する研究(第1報) : 1-Methyl-3「di(2-thienyl)methylene」piperidineおよびそのN-脱メチル体の分離定量法

概要

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A method is described for the fractional determination of 1-methyl-3-[di(2-thienyl)-methylene] piperidine (I) and its N-demethylated derivative (II). The fractional determination was made possible by coloration of II on1y with a Ninhydrin-acetic acid reagent and by coloration of both I and II with a Ninhydrin-su1furic acid reagent after the method of Kase, et al. with minor modifications. By this method one can determine as little as 5 μg of I and 2.5 μg of II per ml of benzene extracts from biological materials. The color reaction with the Ninhydrin-acetic acid reagent may be used also for the determination of several kinds of N-unsubstituted piperidine, morpholine, and pyrrolidine derivatives.
公益社団法人日本薬学会の論文
1969-01-25