γ-ブチロラクトンの利用研究(第14報) : Furoquinoline系Alkaloid "Pteleine"の合成
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概要
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A new furoquinoline alkaloid, pteleine^<3)>, was synthesized by the same route as the synthesis of previously reported furoquinoline alkaloids, i.e. dihydrodictamnine, dihydroevolitrine, kokusaginine, maculine, dihydroskimianine, and 7-hydroxy-8-methoxydihydrodictamnine, Condensation of 5-methoxy-2-nitrobenzoyl chloride and α-acetyl-γ-butyrolactone, in the presence of magnesium, gave 2-(5-methoxy-2-nitrobenzoyl)-γ-butyrolactone and catalytic reduction of its enol-methyl ether, obtained by treatment with diazomethane, afforded 2,3-dihydropteleine. Bromination of 2,3-dihydropteleine with N-bromosuccinimide and subsequent dehydrobromination gave pteleine.
- 社団法人日本薬学会の論文
- 1968-08-25