ナフタレンアルキルアミン類の薬学的研究(第4報) : 2-Naphthalenealkylamine類の薬理作用と熱力学的活量との関係について

概要

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Some considerations were made on the action mechanism of 2-naphthalenealkylamines, with O-7 carbons in the alkyl chain, and their N-alkyl- or N-aralkyl-N-methyl derivatives by measuring their kinetic activity, applying Fergusson's rule to their pharmacological activity. It was thereby found that the atropine-like and antihistamine activities of these compounds are specific action and contribution of the physicochemical properties of the base is very small. On the other hand, their papaverine-like action in the intestine is not so specific like atropine-like activity although in a strong base like the compounds of this series, a certain contribution of the cation is expected. Local anesthetic action was found to be non-specific, being dependent on the physicochemical properties of the non-ionic base or neutral molecule. This fact was further endorsed by the relationship between surface anesthetic action and pH.
公益社団法人日本薬学会の論文
1967-04-25