胆汁酸の代謝(第3報)ケノデオキシコール酸の代謝

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概要

• 論文の詳細を見る

• Metabolism of chenodeoxycholic acid, a therapeutic agent for gallstone dissolution, was examined in rats, hamsters, and rabbits. In the rat liver, chenodeoxycholic acid was found to be converted into taurochenodeoxycholate, a part of which was converted into tauromuricholate. In the rat colon, these conjugated bile acids were hydrolyzed into the corresponding free bile acids and a considerable part of the free chenodeoxycholic acid and muricholic acid were further metabolized to lithocholic acid and hyodeoxycholic acid, respectively, by the action of microorganisms. Main metabolites excreted in the rat feces were identified as muricholic acid, hyodeoxycholic acid, and lithocholic acid. Direct microbial conversion of muricholic acid into hyodeoxycholic acid was established by in vitro experiment in which muricholic acid was incubated with rat feces suspension. Lithocholic acid and its metabolite, 3α, 6β-dihydroxy-5β-cholanoic acid, were not found in the small intestine. It seems likely that lithocholic acid is poorly absorbed after its formation in the colon. In the hamster liver, chenodeoxycholic acid was converted into tauro- and glycochenodeoxycholates. In the hamster intestinal tract, these conjugated bile acids were deconjugated to form chenodeoxycholic acid, which was further metabolized to lithocholic acid. It was found by the double labeled tracer technique using chenodeoxycholic acid [7β-^3H, 24-^<14>C] that a considerable amount of lithocholic acid was reabsorbed from the hamster colon. The absorbed lithocholic acid was completely rehydroxylated to chenodeoxycholic acid. Thus, lithocholic acid was not circulated in the enterohepatic circulation. In the rabbit colon, chenodeoxycholic acid was metabolized to lithocholic acid, a part of which was reabsorbed and reached the liver. In contrast to the hamster, the absorbed lithocholic acid was not hydroxylated in the rabbit liver, and entered into the enterohepatic circulation.

• 公益社団法人日本薬学会の論文
• 1978-01-25

著者

• 角田 創

  広島大学医学部総合薬学科

• 穂下 剛彦

  広島大学医学部衛生化学

• 穂下 剛彦

  広島大学医学部総合薬学科

• 太田 正道

  広島大学医学部総合薬学科

関連論文

• 149 大腸腫瘍における糞中胆汁酸・イソ胆汁酸の分析 : 日本人と米国人との比較・検討(第16回日本消化器外科学会総会)
• Biochemical Studies of Inherited Diseases Related to Abnormal Cholesterol Metabolism. I. High-Performance Liquid Chromatographic Analysis of Bile Alcohol Glucuronides in Cerebrotendinous Xanthomatosis
• 胆汁酸の代謝(第14報)サルコシン抱合胆汁酸
• Synthesis of (24R)-and (24S)-27-Nor-5β-cholestane-3α, 7α, 12α, 24,26-pentols
• Syntheses of 22- and 23-Hydroxylated Bile Alcohols
• 胆汁酸の代謝(第1報)ウルソデオキシコール酸の吸収, 分布, 排泄, および代謝
• Bice Salts of Anura
• 胆汁酸の代謝(第3報)ケノデオキシコール酸の代謝
• コラノイドの比較生化学

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