Cholestanyl Phosphateの研究(第1報) : 3β-および3α-Cholestanyl Phosphateの合成と抗炎症作用

概要

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In order to examine their anti-inflammatories activity 3β-(VIa) and 3α-cholestanyl phosphate (VIb) were synthesized. The reaction of 3β-(Ia) and 3α-cholestanol (Ib) with phosphoryl chloride at a low temperature, followed by hydrolysis of products, afforded 3α-(VIa) and 3β-cholestanyl phosphate (VIb) in a good yield. In addition, phosphorylation of Ia and Ib were investigated with diphenyl phosphorochloridate, dibenzyl phosphoro-chloridate, and β-cyanoethyl phosphate. Significant anti-inflammate effect, such as inhibition of edema formation in carrageenin-and albumin-injected rats, inhibition of granuloma formation with cotton pellets implanted under the skin of rats, was recognized in 3β-cholestanyl phosphate.
公益社団法人日本薬学会の論文
1977-05-25