カフェインWhisker(ヒゲ結晶)の顆粒剤からの発生・成長

概要

論文の詳細を見る
Needle-like crystals of caffeine, the so-called whiskers, were found to grow on the surfaces of granules containing caffeine and some of ingredients during storage under accelerated conditions of temperature with time. Growth of the whiskers was promoted by ingredients in the granules which were glycyrrhizic acid, pluronic F68,and hydroxypropyl-cellulose (HPC-L), whereas growth was scarcely observed on the granules free from one of these ingredients. A great effect of humidity and temperature on the susceptibility to whisker growth was recognized. It was proved by microscopic observations and various experiments that caffeine whiskers were non-proper whiskers which grew at the fiber tip, not at the bottom, from caffeine molecules in the vapor phase surrounded by a crystal lattice, on the growth face of caffeine crystals.
公益社団法人日本薬学会の論文
1976-10-25