モルモット尿中の非透析法β-Glucuronidase阻害物質(第2報)性状
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Properties of non-dialyzable β-glucuronidase inhibitor isolated from guinea-pig urine were examined by using the calf liver β-glucuronidase (ketodie). It was a heat stable inhibitor of β-glucuronidase. Kinetic studies indicated that the substance functions as a non-competitive inhibitor and it was a relatively specific inhibitor for β-glucuronidase. The inhibitory activity of purified inhibitor on β-glucuronidase was stronger than those of acid mucopolysaccharides. chondroitin sulfate A, B, and C, heparin, and hyaluronic acid. Electrophoretic pattern of the purified inhibitor was completely different from those of the latter substances.
- 公益社団法人日本薬学会の論文
- 1975-10-25
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