ピリミジン誘導体の合成研究(第3報)Pyrimido[1,2-c]quinazoline, Imaidazo[1,2-c]quinazoline誘導体の合成
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概要
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Reaction of the derivatives of 4-chloroquinazoline with aminoalcohol afforded 4-(3-hydroxypropylamino) quinazoline (IIIa) and 4-(2-hydroxyethylamino) quinazo1ine (IIIe). The hydroxyl group in IIIa and IIIe was substituted with chlorine by phosphoryl chloride. Further, the chlorinated carbon was bonded to the non-conjugated electron pairs of the nitrogen atom in the quinazoline ring, and six- and five-membered ring was formed. As a result, the quaternary salt (V) of 1,2,3,4-tetrahydropyrimido- and 2,3-dihydro-1H-imidazo[1,2-c]quinazo1inium chloride derivatives were obtained. The free base (VI) corresponding to V was produced by treatment with 10% sodium hydroxide solution. On the other hand, sulfuric acid so1ution of IIIa or IIIe was treated with nitrosyl sulfate and subsequently with sodium hydroxide solution to afford VI from both.
- 公益社団法人日本薬学会の論文
- 1974-04-25
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関連論文
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- ピリミジン誘導体の合成研究(第3報)Pyrimido[1,2-c]quinazoline, Imaidazo[1,2-c]quinazoline誘導体の合成