ChloromethacrylonitrileおよびChloroisobutyronitrileに関する研究(第2報)MethacrylonitrileおよびChloromethacrylonitrileの高温気相塩素化

概要

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Chlorination of methacrylonitrile (1) was carried out at an elevated temperature in a continuous vapor phase reaction vessel, and the products were isolated by fractional distillation or gas chromatography and their structures confirmed. 3-Chloro-2-chloromethylacrylonitriles (trans and cis isomers, 5a and 5b) which are useful intermediates for the tbiamine synthesis were obtained together with some monochloro derivatives, 3-chloro-2-methylacrylonitrile (2), 2-chloromethylacrylonitrile (3), and 2-chloro-2-chloromethylpropionitrile (4). These monochloro compounds were rechlorinated under a similar condition and dichloro compounds (5a and 5b) were obtained from each monochloro compound.
公益社団法人日本薬学会の論文
1973-10-25