製剤中アルジオキサの吸光度定量

概要

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A spectrophotometric analytical method for the determination of aldioxa (AL), an anti-peptic ulcer agent, in pharmaceutical preparations has been established. Hydrolysis of AL gives allantoic acid (AA) which is transformed into glyoxylic acid (GA) in the presence of hydrochloric acid. GA reacts with phenylhydrazine to form Shiff base, glyoxylic acid phenylhydrazone (GAP), which has an absorption maximum at 335 nm. The correlation coefficient between the absorbance and amount of AL was 0.999,and the coefficient of variation 0.33-0.63%. This method is considered to be useful for the routine analysis of AL in pharmaceutical preparations.
1983-10-25