3-Ureido-2-pyrazolin-5-one類の合成

概要

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The synthetic method of 3-ureido-2-pyrazolin-5-ones by use of 3-phenoxycarbonylamino-2-pyrazolin-5-ones and amines was developed. This method is superior to that by using 3-amino-2-pyrazolin-5-ones and isocyanates with respect to the following facts. 1) This method is not influenced by the presence of moisture. 2) Starting materials of this method are considerably stable in storage. 3) Not only 3-N'-mono-substituted ureido-2-pyrazolin-5-ones but also 3-N', N'-di-substituted ureido derivatives are obtained by this method. 4) Without protecting group, substituents having hydroxy or amino group are introduced into 3-ureido-2-pyrazolin-5-ones by this method. 3-Ureidoanilino-2-pyrazolin-5-ones are also synthesized from 3-phenoxycarbonylaminoanilino-2-pyrazolin-5-ones and amines.
公益社団法人日本薬学会の論文
1981-04-25