アルギン酸ナトリウムの線溶に対する作用

概要

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The fibrinolytic activity in the presence of sodium alginate was examined. The inhibitions of fibrin degradation by plasmin were observed by the fibrin agar plate method or the dissolution method of fibrin suspension. The same result was obtained by testing the fibrin agar plate made from the fibrinogen and thrombin or the solubility of the fibrin clot made from fibrinogen and thrombin in the presence of sodium alginate. The solubility of clot prepared from euglobulin in the rat plasma was prolonged. The effect of sodium alginate on fibrinolysis was very weak compared with that of tranexamic acid. The hydrolytic activities of plasmin against substrate S-2251 and TAME were not inhibited by sodium alginate. This result suggests that the antifibrinolytic effect of sodium alginate may be based on the interaction of fibrin or fibrinogen and sodium alginate.
社団法人日本薬学会の論文
1987-01-25