オピオイド受容体における分子認識と創薬研究

概要

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For understanding the three-dimentional mechanisms that control potency and selectivity of the ligand binding at the atomic level, we have analysed opioid receptor-ligand interaction based on the receptor's 3D model. The analyses of the interactions of some opioid ligands with the predicted ligand binding sites are consistent with the results of the affinity labeling experiments. On the basis of the three-dimentional structures of the putative binding sites in the opioid receptors, a potent κ agonist KT-95 was designed in our laboratory.
公益社団法人日本薬学会の論文
1998-01-01