動物細胞表面膜の細胞外Adenosine Triphosphateによる透過性調節と化学療法への応用

スポンサーリンク

概要

• 論文の詳細を見る

• External adenosine triphosphate (ATP) has been shown to induce permeability changes in a variety of animal cells. This review is mainly concerned with the effect of external ATP on passive permeability of transformed cells in culture. Brief exposure of several transformed cells to ATP causes a striking increase in passive permeability, allowing passage through the plasma membrane of phosphorylated metabolites and ions. Untransformed fibroblasts do not respond to the ATP. Although the molecular mechanisms of this permeability change in transformed cells are largely unknown, it has been demonstrated that the permeability change is modulated by cellular ATP, cytoskeleton and calmodulin. These characteristics and the recent studies with an isolated ATP-resistant variant designed to gain some insight into the biochemistry and regulation of the ATP effect are summarized. By considering a selective effect of external ATP on membrane permeability of transformed cells, possible application of this method to cancer chemotherapy has been examined. The results obtained mainly with in vitro systems are also described.

• 公益社団法人日本薬学会の論文
• 1988-07-25

著者

• 北川 隆之

  岩手医科大学薬学部OSCE準備委員会

• 北川 隆之

  国立予防衛生研究所化学部

関連論文

• 21-P3-538 岩手医科大学薬学部におけるOSCEミニトライアルの実施と検証(薬学教育(OSCE),来るべき時代への道を拓く)
• ATPを用いた化学療法の抗腫瘍効果増強に関する実験的研究(第30回日消外会シンポ2:消化器実験外科の進歩と新しい展開)
• 動物細胞表面膜の透過性調節機構とその薬学的応用
• 増殖因子による動物細胞のグルコ-ス輸送制御
• 癌化とグルコ-ストランスポ-タ- (グルコ-ストランスポ-タ-)
• 動物細胞表面膜の細胞外Adenosine Triphosphateによる透過性調節と化学療法への応用
• 生体膜関連の本・論文誌
• ATPによる動物細胞表面膜の透過性調節
• Different Sensitivities to External ATP in Passive Permeability of Transformed Mouse Cell Lines
• ATPによる動物細胞表面膜の透過性変化とその利用

スポンサーリンク