パラジウム触媒を用いたアミノアレンのアジリジン化及びアゼチジン化反応の開発
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概要
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Palladium-catalyzed synthesis of alkenylaziridines and azetidines from α- and β-amino allenes are presented. Whereas palladium-catalyzed reaction of N-arylsulfonyl-α-amino allenes with an aryl iodide in the presence of potassium carbonate in DMF at around 70℃ affords the corresponding 3-pyrroline derivatives, the reaction in refluxing 1, 4-dioxane under similar conditions yields exclusively or most predominantly the corresponding 2-alkenylaziridines bearing an aryl group on the double bond. Similarly, N-arylsulfonyl-β-amino allenes can be also cyclized into the corresponding alkenylazetidines bearing 2, 4-cis-sunstituents under palladium-catalyzed cyclization conditions in DMF.
- 公益社団法人日本薬学会の論文
- 2001-10-01
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関連論文
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- パラジウム触媒を用いたアミノアレンのアジリジン化及びアゼチジン化反応の開発