新規抗真菌抗生物質Bacillopeptins及びFusaricidinsについて(総合論文)

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概要

• 論文の詳細を見る

• We isolated four strains of bacteria producing antifungal antibiotics from the rhizosphere of garlic with basal rot caused by the plant pathogenic fungal strain Fusarium oxysporum. Among them, Bacillus subtilis FR-2 was found to produce new antifungal antibiotics, named bacillopeptins A, B, and C. Their structures have been determined by ID and 2D NMR and MS experiments, and amino acid analysis coupled with chiral HPLC, to be cyclic lipopeptides each containing a long-chain β-amino acid. Another bacterial strain, Bacillus polymyxa KT-8, was shown to produce new antifungal antibiotics named fusaricidins A, B, C, and D which are more potent than bacillopeptins in their antimicrobial activity. The structures of the fusaricidins have been elucidated similarly as bacillopeptins to be cyclic hexadepsipeptides all containing 15-guanidino-3-hydroxypentadecanoic acid as a side chain. Fusaricidins strongly inhibit the growth of various kinds of fungi and moreover surprisingly show strong inhibitory activity against Gram-positive bacteria such as Staphylococcus aureus or Micrococcus luteus.

• 公益社団法人日本薬学会の論文
• 2002-09-01

著者

• 金田 幸

  広島大学大学院医歯薬学総合研究科

• 梶村 芳雄

  湧永製薬株式会社中央研究所

関連論文

• 新規抗真菌抗生物質Bacillopeptins及びFusaricidinsについて(総合論文)

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