Acute and Subacute Toxicity Test of 2-Azido-4-isopropylamino-6-methylthio-8-triazine (Aziprotryne, C-7019)

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概要

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• The acute and subacute toxicity test of the selective herbicide, 2-azido-4-isopropylamino-6-methylthio-s-triazine (C-7019), newly developed by Ciba-Geigy Ltd., was examined, and results obtained were as follows : Acute toxicity (LD_<50>) value by oral administration after 48 hr was 2970 mg/kg (2434-3929 mg/kg) for male mice and was 3600 mg/kg (2951-4392 mg/kg) for male rats. Sedation, ataxia, and respiratory depression were the amin toxic signs. Intraperitoneal LD_<50> value after 48 hr was 265 mg/kg (217-323 mg/kg) in male mice. Toxic symptoms of C-7019 by intraperitoneal administration differed from that of oral administration. Central excitation was observed which was then followed by toxic symptoms of oral administration. Three-month subacute toxicity test of C-7019 was carried out on mice and rats at dosage levels of 30,50,100,and 400 mg/kg/day in the diet, but the amount actually consumed was less than the planned dosages. No abnormal behavior due to toxicity was noted that could be related to C-7019,and no animals died in any of the groups during the experiment. Except for slightly reduced rate of body weight gain in rats, no remarkable differences compared to controls were observed in daily food consumption, growth (weight change) in mice, effect on blood (number of erythrocytes and leucocytes, hemoglobin, platelets, and blood picture), renal functions (urinary pH. glycosuria, proteinuria), liver functions (urobilinogen, bilirubin, activities of serum transaminase), or macroscopic observations on internal organs, their weight, and weight ratio. Animals which received C-7019 showed no adverse histopathological changes which could be related to C-7019 in the brain, lung, thymus, adrenal, spleen, testis, ovary, or bone marrow, except the infiltration of perivascular round cells in kidneys and focal cell infiltration in hepatic cells.

• 公益社団法人日本薬学会の論文
• 1971-10-30

著者

• MOTOI ETSUKO

  Kobe Women's College of Pharmacy

• MURASAWA KENSUKE

  Cancer Research Institute, Kanazawa University

• Motoi Etsuko

  Kobe Women's College Of Pharmacy

• Murasawa Kensuke

  Cancer Research Institute Kanazawa University

関連論文

• Acute and Subacute Toxicity Test of 2-Azido-4-isopropylamino-6-methylthio-8-triazine (Aziprotryne, C-7019)

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