クロロフェノール類のヒメダカへの急性毒性と胚の孵化阻害性及び構造との相関

概要

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Acute toxicities and hatching inhibitions of embryo by 14 chlorophenols from mono-Cl to penta-Cl and phenol to Japanese Medaka, Oryzias latipes, have been determined as 96 h-LC_<50> and 15 d-EC_<50>, respectively and studied in terms of quantitative structure-activity relationship (QSAR). The 6 physico-chemical parameters of chlorophenols employed in this study were : n-octanol/water partition coefficient, log P_<ow> ; dissociation constant, pK_a ; Hammett constant, Σσ ; index of valence molecular connectivity, ^1X^v ; perimeter of the efficient cross section of molecule, ΣD ; melting point, F. On the whole, acute toxicity and hatching inhibition of chlorophenols increase with a degree of chlorination and ortho-isomers appear as less toxic than meta-and para-isomers. QSAR study shows that log P_<ow>, a parameter of hydrophobicity, gives the best correlation with the activity. With regard to each chlorophenol, 96 h-LC_<50> of Oryzias latipes agrees with that of another kind of fish, Lebistes reticulatus (guppy). High correlations were found among 96 h-LC_<50> and 15 d-EC_<50> values of Oryzias latipes, EC_<50> values of growth inhibition of green algae, Selenastrum capricornutum and EC_<50> values of immobilization of Daphnia magna, Daphnia carinata and Daphnia pulex.
公益社団法人日本薬学会の論文
1988-08-30