Mutagenic Activities of Commercial Sudan III and Scarlet Red are Due to Impurities

概要

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Commercial samples and pure chemical samples of Sudan III (C. I. 26100) and Scarlet Red (C. I. 26105) were tested for mutagenic activities in the Ames test. Three out of five commercial samples of Sudan III were mutagenic to Salmonella typhimurium TA98 and TA100 in the presence of S9 mix, and all of the commercial samples of Scarlet Red tested were mutagenic to the two strains with microsomal activation. Neither of the purified dyes, however, was mutagenic to these strains with or without S9 mix. These results demonstrate that contaminants present in these commercial diazodyes were responsible for the mutagenic activity. Some of the contaminants were separated by preparative thin layer chromatography, and the starting materials of the azo-dyes, i. e. p-aminoazobenzene (AB) and o-aminoazotoluene (oAT), were found to be the main mutagenic contaminants.
公益社団法人日本薬学会の論文
1985-04-30