二酸化窒素の実験動物に及ぼす影響
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概要
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The acute and subacute effects of exposure of rats to nitrogen dioxide (NO_2) at low levels on lung, liver and red blood cells were examined biochemically and cytologically. In addition, influences of nitrate and nitrite, chemical intermediates of inhaled NO_2,on red blood cells and hepatic microsomes were examined in vitro to clarify the mechanisms responsible for in vivo effects of NO_2. The biological significance of responses to NO_2 was discussed with respect to physiological adaptation to low levels of NO_2. I. In the lung, a metabolic enhancement developed in several days of NO_2 inhalation. This was followed by an increase in alveolar cells such as macrophages and Type II epithelial cells. These results suggest that epithelial cells increase as a response compensating degeneration of lung cells produced by NO_2 inhalation. II. In the blood, an initial response to NO_2 inhalation was an increase in younger red blood cells. This increment seems to occur as compensation for accelerated aging of red blood cells presumably induced by NO_2 inhalation. Some membrane constituents of red blood cells were decreased initially by NO_2 inhalation. This decrement was due to an increasing level of blood nitrate produced by NO_2 inhalation. III. In the lung and liver, NO_2 inhalation periodically decreased the components of microsomal drugmetabolizing systems and mitochondrial respiratory system. These periodic alterations appear to be a reflex of degeneration of membranous components and subsequent stimulation of biosynthesis. It is also suggested that hepatic microsomal components decrease due to a reaction of blood nitrate increased by NO_2 inhalation.
- 公益社団法人日本薬学会の論文
- 1984-12-31