Effect of Age on the Distribution of Cadmium in Rat Tissues

概要

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Young (1.5-month-old) and adult (12-month-old) Wistar female rats were used to study the influence of age on the distribution of cadmium. One-half of each group was injected subcutaneously with CdCl_2 (1.0 mg of Cd/kg body weight) in saline and the other rats in each group received saline alone (0.5 ml/kg) every day for 2 weeks. Exposure to cadmium resulted in an increase of cadmium and zinc in the liver and kidneys. The Cd/Zn ratio in the kidneys was significantly greater in the 12-month-old rats than in the 1.5-month-old rats, although the concentration of cadmium in the former was only slightly greater than that in the latter. Most of the accumulated cadmium in the kidneys was bound to metallothionein in both groups. The Cd/Zn ratio in renal metallothionein was significantly greater in the 12-month-old rats than in the 1.5-month-old rats. These results suggest that there are some differences in the metabolism of zinc and/or cadmium in the kidneys, particularly in relation to metallothionein, between 1.5- and 12-month-old rats.
公益社団法人日本薬学会の論文
1983-02-28