熊胆など数種の動物胆および各種胆汁酸の腸管系細菌の発育におよぼす影響

概要

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Effect of bear, ox, pig, and wild boar galls, in which bile acid components had been analyzed quantitatively, and various bile acids on growth of intestinal bacteria was investigated. 1) Free deoxycholic, chenodeoxycholic, and ursodeoxycholic acids showed strong antibacterial activities, whereas the antibacterial activities of their conjugated acids decreased distinctively. 2) Chenodeoxycholic acid has antibacterial potency as strong as that of deoxycholic acid on anaerobic Clostridium butyricum and Bacteroides fragilis. 3) Salmonella enteritidis and Escherichia coli were not inhibited in the medium containing 1% (w/v) of any of the bile acids and animal galls tested. 4) Streptococcus faecalis was affected by free deoxycholic and chenodeoxycholic acids and a certain sample of bear gall. Growth of Bacteroides fragilis was inhibited by every free bile acid tested, and that of Clostridium butyricum was inhibited by all the free bile acids except cholic acid. 5) The results obtained from the tests of ox and pig gall suggest that these galls contain a component responsible for overcoming the antibacterial activities of bile acids on anaerobic bacteria.
公益社団法人日本薬学会の論文
1975-02-28