Preventive Effect of the Extract of Du-Zhong (Tochu) Leaf and Ginseng Root on Acute Toxicity of Chlorpyrifos

スポンサーリンク

概要

• 論文の詳細を見る

• The preventive effects of the extract (DP-extract) prepared from leaves of Eucommia ulmoides OLIVER, Eucommiaceae (Du-Zhong leaf) and roots of Panax ginseng C.A. MEYER (Ginseng), which are widely used as healthful teas, on acute toxicity of chlorpyrifos, a common organophosphorus insecticide, were investigated in mice. A 50% lethal dose of chlorpyrifos was 16.9% higher in the group pretreated with DP-extract for 3 weeks (6.66 g of dried leaves and root/kg/d, p.o.) than in the chlorpyrifos alone group. Cholinesterase (ChE) activities in serum were higher and the residual chlorpyrifos in liver was lower in mice pretreated with DP-extract than in the chlorpyrifos-alone group. Hepatic cytochrome P450 content, activities of NADPH-cytochrome c reductase and carboxylesterase (EC3.1.1.1) in livers of DP-extract pretreated mice were significantly higher than those of untreated control immediately after chlorpyrifos injection. The activities of those enzymes were also significantly higher in the DP-extract pretreated mice than the controls. Northern blot analysis of microsomes from livers of DP-extract pretreated mice revealed the increased transcription of NADPH-cytochrome c reductase and carboxylesterase. These results suggest that DP-extract increased the activities of cytochrome P450 and carboxylesterase and accelerated detoxification of chlorpyrifos to prevent the acute toxicity of the organophosphorus insecticide.

• 社団法人日本薬学会の論文
• 1997-04-30

著者

• 日下部 守昭

  理研・実験動物

• 古津 みを

  Department of Biochemistry, College of Pharmacy, Nihon University

• 小山 洋一

  Division of Experimental Animal Research, Tsukuba Life Science Center, The Institute of Physical and

• 日下部 守昭

  Division of Experimental Animal Research, Tsukuba Life Science Center, The Institute of Physical and

• 高橋 周七

  Department of Biochemistry, College of Pharmacy, Nihon University

• 小山 洋一

  Division Of Experimental Animal Research Tsukuba Life Science Center The Institute Of Physical And C

• 古津 みを

  Department Of Biochemistry College Of Pharmacy Nihon University

関連論文

• B2 乳癌細胞の腫瘍成長と転移におけるテネイシン誘導因子の影響
• 新しい胎仔間充組織由来テネイシン誘導因子
• CSA/PBP74プロモーターの各種ストレスに対する応答性の解析
• 研究室だより 理化学研究所・ライフサイエンス筑波研究センター・実験動物室--実験動物リソースの確立を目指して
• B-6 慢性のアレルギー性接触皮膚炎における細胞外マトリックスの機能 : 細胞外マトリックス蛋白質の発現と分布
• Preventive Effect of the Extract of Du-Zhong (Tochu) Leaf and Ginseng Root on Acute Toxicity of Chlorpyrifos
• Chemical Studies on the Oriental Plant Drugs. XX. The Constituents of Cassia tora L. (1). The Structure of Torachrysone
• II-C-1 杜仲葉人参エキスの Chlorpyrifos (有機リン系農薬)解毒活性について

スポンサーリンク