無水硫酸ナトリウムを用いる血液及び尿からのモルヒネの脱水抽出法
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We investigated an extracting method of morphine having rapidity, low cost, simplicity and high recovery. The samples containing morphine were dehydrated by adding anhydrous sodium sulfate and extracted by dichloromethane with shaking in the presence of anhydrous sodium sulfate. Morphine could be extracted by the dehydrating action of anhydrous sodium sulfate more efficiently as compared with the liquid-liquid extraction method using dichloromethane. After derivatization with pentafluoropropionic anhydride, morphine was determined with gas chromatography/mass spectrometry (GC/MS) by the selected ion monitoring (SIM) mode. Ethylmorphine was used as an internal standard. The recoveries from 3 ml of urine and hydrolyzed urine containing 830.1ng of morphine were 93.6% and 94.7%, respectively. The recoveries from 3 ml of blood and hydrolyzed blood containing 207.6 ng of morphine were 76.9% and 93.9%, respectively. The standard deviations (n=5) of the recoveries from urine, hydrolyzed urine, blood and hydrolyzed blood were 3.6%, 4.1%, 6.6% and 2.3%, respectively.
- 公益社団法人日本薬学会の論文
- 1996-04-30
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- 無水硫酸ナトリウムを用いる血液及び尿からのモルヒネの脱水抽出法