High-Performance Liquid Chromatographic Determination of Triazolam in Biological Fluids
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概要
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We describe the simple, rapid and sensitive quantitation of triazolam in human biological fluids by an HPLC with solid-phase extraction. Triazolam was extracted from human plasma with an excellent recovery with Bond Elut CN-E as a solid-phase extraction column. The extract was then applied to HPLC fitted with a C8 column. The effluent was monitored by UV detection at 230 nm. The validation results indicate that the method showed excellent intra- and inter-assay precision and accuracy with high sensitivity. The low limit of quantitation was 0.2 ng/ml when 2 ml of plasma sample was available. The method was successfully applied to plasma, urine and effluent of gastric lavage collected from patients.
- 公益社団法人日本薬学会の論文
- 1994-02-28
著者
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立石 満
Drug Metabolism And Analytical Chemistry Research Upjohn Pharmaceuticals Limited Tsukuba Research La
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小松 栄
Drug Metabolism and Analytical Chemistry Research, Upjohn Pharmaceuticals Limited, Tsukuba Research
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村田 祥一
Drug Metabolism and Analytical Chemistry Research, Upjohn Pharmaceuticals Limited, Tsukuba Research
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青山 裕之
Drug Metabolism and Analytical Chemistry Research, Upjohn Pharmaceuticals Limited, Tsukuba Research
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善木 智子
Drug Metabolism and Analytical Chemistry Research, Upjohn Pharmaceuticals Limited, Tsukuba Research
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村田 祥一
Drug Metabolism And Analytical Chemistry Research Upjohn Pharmaceuticals Limited Tsukuba Research La
-
小松 栄
Drug Metabolism And Analytical Chemistry Research Upjohn Pharmaceuticals Limited Tsukuba Research La
-
善木 智子
Drug Metabolism And Analytical Chemistry Research Upjohn Pharmaceuticals Limited Tsukuba Research La
-
青山 裕之
Drug Metabolism And Analytical Chemistry Research Upjohn Pharmaceuticals Limited Tsukuba Research La