メチル水銀の体内動態

概要

論文の詳細を見る
Methylmercury is an environmental pollutant well known as a cause for a severe neurologic symptom. This review summarizes recent studies of tissue transport mechanism of methylmercury in experimental animals. Methylmercury has high affinity for sulfhydryl groups such as glutathione (GSH ; γ-glutamylcysteinylglycine) and methylmercury-GSH complex has been detected in animal tissues. GSH is a major intracellular nonprotein sulfhydryl compound in several animal tissues and plays a key role in detoxication and elimination of many xenobiotics, which form GSH-S-conjugates enzymatically, in cooperation with GSH-metabolizing enzymes. In this review, the role of GSH and GSH-metabolizing enzymes in metabolism of methylmercury are discussed in relation to the mechanisms of the transport, accumulation and excretion of methylmercury which reversibly binds to GSH.
公益社団法人日本薬学会の論文
1993-12-31