Study for Catecholamine-2'-Deoxyguanosine Adduct Formation under Biomimetic Conditions Using Liquid Chromatography-Electrospray Ionization-Ion Trap Mass Spectrometry
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概要
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The adduct formation of 2'-deoxyguanosine(dG)with L-adrenaline under biomimetic conditions(pH 7.5, 37℃)with or without oxidant(MnO_2)was demonstrated in order to clarify the reaction mechanism and the structure. At least two adducts have been observed by liquid chromatography-electrospray ionization-ion trap mass spectrometry(LC-ESI-ion trap MS)and LC-photodiode array detection(LC-PAD)(compound a : more polar than dG, m/z 463(M+H)^+, λmax : 230, 320 nm ; compound b : less polar than dG, m/z 445(M+H)^+, λmax : 220, 240, 320, 405 nm). Compound a appeared only in the early stage of the reaction prior to formation of compound b.
- 公益社団法人日本薬学会の論文
- 2001-08-01
著者
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Oe Tomoyuki
Department Of Analytical Chemistry School Of Pharmaceutical Sciences University Of Shizuoka:(present
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Oe Tomoyuki
Department Of Analytical Chemistry School Of Pharmaceutical Sciences University Of Shizuoka
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Matsumoto Syuhei
Department of Analytical Chemistry, School of Pharmaceutical Sciences, University of Shizuoka
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Matsumoto Syuhei
Department Of Analytical Chemistry School Of Pharmaceutical Sciences University Of Shizuoka:(present
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Toyo'oka T
Department Of Analytical Chemistry School Of Pharmaceutical Sciences University Of Shizuoka
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