Investigation of the Effects of Tamsulosin on Blood Pressure in Normotensive, Controlled Hypertensive, and Uncontrolled Hypertensive Men with Benign Prostatic Hyperplasia

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Up to the mid-1990s benign prostatic hyperplasia (BPH) was commonly treated surgically. However, surgery is associated with numerous instances of failure, high patient morbidity rates, and substantial annual costs. Tamsulosin, an α_1-adrenergic receptor antagonist, was originally developed as an alternative to surgery for BPH. It significantly improves urinary obstruction by relaxing smooth muscle in the bladder neck and prostate via specific inhibition of the α_1-adrenergic receptor subtype, the predominant subtype in these tissues. However, since α_1-adrenergic receptors also mediate constriction of smooth muscle in the vascular wall, extensive tests were carried out during phase III clinical trials to investigate whether tamsulosin has any effect on mediation of the cardiovascular system. Since BPH is a condition that affects men from middle age and many patients are also hypertensive, a subanalysis was carried out during these phase III clinical trials to investigate whether tamsulosin has any effect on blood pressure control or vasodilation in men who are also being treated for hypertension. During 13-week double-blind administration of once-daily tamsulosin or placebo, no statistically significant differences were observed in blood pressure or heart rate among normotensive, controlled hypertensive, and uncontrolled hypertensive patients. The results of this study demonstrate that tamsulosin can be used in BPH patients who are hypertensive without any restrictions on blood pressure control medication.
公益社団法人日本薬学会の論文
2001-04-01

Investigation of the Effects of Tamsulosin on Blood Pressure in Normotensive, Controlled Hypertensive, and Uncontrolled Hypertensive Men with Benign Prostatic Hyperplasia

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