Anti-diabetic Activity Present in the Fruit Body of Grifola frondosa (Maitake). I

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概要

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• The fruit body of Grifola frondosa (maitake), Basidiomycetes was confirmed to contain substances with anti-diabetic activity. When 1g/d of powdered fruit body of maitake was given orally to a genetically diabetic mouse (KK-A^y), blood glucose reduction was observed, in contrast to the control group in which the blood glucose increased with ageing. Moreover, levels of insulin and triglyceride in plasma demonstrated a change similar to blood glucose with feeding of maitake. Ether-ethanol-soluble (ES) and hot water-soluble (WS) fractions were prepared from the fruit body and their hypoglycemic activity was examined. Blood glucose-lowering activity was found when ES-fraction or WS-50% ethanol float (X) fraction was administered orally, but other WS-fractions were inactive. These results suggest that the anti-diabetic activity was present not only in the ES-fraction consisting of lipid but also in the X-fraction of peptidoglycan (sugar : protein=65 : 35).

• 1994-08-15

著者

• 難波 宏彰

  Department of Microbiology, Kobe Women's College of Pharmacy

• 青木 久夫

  Aoki Clinic

• 難波 宏彰

  Department Of Microbial Chemistry Kobe Pharmaceutical University

• 久保 恵子

  Yukiguni Maitake Co. Ltd.(present Address):department Of Microbial Chemistry Kobe Pharmaceutical Uni

関連論文

• Anti-diabetic Activity Present in the Fruit Body of Grifola frondosa (Maitake). I
• Blood Pressure-Lowering Activity Present in the Fruit Body of Grifola frondosa (Maitake). I
• Potentiation of Host-Mediated Antitumor Activity by a β-Glucan Derived from Mycelia of Cochliobolus miyabeanus(Biological)
• Potentiation of Host-Mediated Antitumor Activity in Mice by β-Glucan Obtained from Grifola frondosa (Maitake)(Biological)

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