Promotion of Neuronal Differentiation of PC12h Cells by Natural Lignans and Iridoids

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概要

• 論文の詳細を見る

• We studied the effect of (+)- and (-)-syringaresinol, (+)-syringaresinol glucosides, syringin, aucubin and catalpol on neurite outgrowth of a cultured cell line of paraneuron, PC12h cells. Of these compounds, (+)-syringaresinol diglucoside and partly glucosidase-hydrolyzed aucubin were found to be the most potent in promotion of the neurite outgrowth and stimulated responses to a high concentration of KCl and to carbachol in the cells, as observed by increase of the concentration of cytosolic free calcium. It is suggested that some of these herb-derived compounds can induce neuronal differentiation in PC12h cells.

• 1994-12-15

著者

• 千葉 賢三

  北陸大学 薬

• 山崎 真津美

  北陸大学 薬

• 山崎 眞津美

  北陸大・薬・生物活性

• 山崎 眞津美

  2nd Division of the Research Laboratory for Development of Medicine, Hokuriku University

• 広田 克則

  2nd Division of the Research Laboratory for Development of Medicine, Hokuriku University

• 千葉 賢三

  2nd Division of the Research Laboratory for Development of Medicine, Hokuriku University

• 毛利 哲郎

  2nd Division of the Research Laboratory for Development of Medicine, Hokuriku University

• 広田 克則

  2nd Division Of The Research Laboratory For Development Of Medicine Hokuriku University

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