Proteinuric Potentials of Angiotensin II, [des-Asp^1]-Angiotensin II, and [des-Asp^1,des-Arg^2]-Angiotensin II in Rats

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概要

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• To compare proteinuric potentials among angiotensin II (ANG II) and its fragments, [des-Asp^1]-angiotensin II (ANG III) and [des-Asp^1,des-Arg^2]-angiotensin II (ANG IV), the peptide was intravenously infused for 30 min at doses of 0.015,0.05,0.15,0.45 and 1.45 nmol/kg body weight/min. The infusion of ANG II and ANG III increased the fractional clearance of albumin in a dose-dependent manner : most extensively for ANG II, and moderately for ANG III. In contrast, the infusion of ANG IV hardly showed any proteinuric action, even at the maximal dose of 1.45 nmol/kg body weight/min. These results denoted that the cleaving of the N-terminal aspartic acid^1 from ANG II weakened the proteinuric action in the glomeruli, and the further cleaving of the N-terminal arginine^2 from ANG III led to a complete loss of proteinuric action in the glomeruli.

• 1994-11-15

著者

• 須藤 純一

  Department Of Clinical Pharmacology And Toxicology Faculty Of Pharmaceutical Sciences Health Science

• 照井 潤

  Department Of Clinical Pharmacology And Toxicology Faculty Of Pharmaceutical Sciences Health Science

• 田元 浩一

  Department of Immunology and Microbiology Faculty of Pharmaceutical Sciences, Health Sciences Univer

• 田元 浩一

  Department Of Immunology And Microbiology Faculty Of Pharmaceutical Sciences Health Sciences Univers

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