AUTOOXIDATION OF ALKYLHYDRAZONES AND MUTAGENICITY OF THE RESULTING HYDROPEROXIDES

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概要

• 論文の詳細を見る

• Acetone alkylhydrazones were readily autooxidized to 2-alkylazo-2-propyl hydroperoxides, which were directly mutagenic in Salmonella typhimurium TA1535,TA100,TA102 and Escherichia coli WP2hcr^-. The mechanism of this mutagenicity presumes that the hydroperoxides in aqueous solution decompose to alkyl diazonium ions which were observed in the alkylation of 4-(p-nitrobenzyl)pyridine, and also to hydroxyl radical which was detected by ESR.

• 社団法人日本薬学会の論文
• 1993-01-15

著者

• 伊藤 啓

  共立薬科大学

• 望月 正隆

  Kyoritsu College of Pharmacy

• 道廣 幸三

  Kyoritsu College of Pharmacy

• 塩見 佳津子

  Kyoritsu College of Pharmacy

• 伊藤 啓

  Kyoritsu College of Pharmacy

• 丹下 佳子

  Kyoritsu College of Pharmacy

• 膝舘 祥治

  Kyoritsu College of Pharmacy

関連論文

• AUTOOXIDATION OF ALKYLHYDRAZONES AND MUTAGENICITY OF THE RESULTING HYDROPEROXIDES
• Reaction Mechanism in Aromatic Heterocyclic Compounds. X. Kinetics of the Reaction of Carcinogenic 4-Nitroquinoline 1-Oxide and Its Derivatives with Sodium Ethoxide
• Dealkylation of N-Nitrosodibenzylamine by Metalloporphyrin/Oxidant Model Systems for Cytochrome P450
• Activation of N-Nitrosodialkylamines to Mutagens by a Metalloporphyrin : Oxidant Model System for Cytochrome P450

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