Gastric Anti-ulcer Activity of Several α, β-Unsaturated Carbonyl Compounds in Rat

概要

論文の詳細を見る
The gastric cytoprotective activity of several molecules containing an α, β-unsaturated carbonyl system is reported. We attributed this gastroprotective activity to the presence of a non-hindered Michael acceptor in the molecules assayed and suggested that the mechanism of protection would involve, at least in part, a nucleophilic attack of the sulphydryl group of the gastric mucosa to the β carbon of the Michael acceptors of the compounds assayed.
公益社団法人日本薬学会の論文
2000-05-01