Cytotoxic Effects of Pyridino[2,3-f]indole-4,9-diones on Human Tumor Cell Lines

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概要

• 論文の詳細を見る

• The cytotoxicities of pyridino[2,3-f]indole-4,9-dione derivatives were examined against human lung tumor cell lines (A 549), human ovarian tumor cell lines (SK-OV-3), human melanoma tumor cell lines (SK-MEL-2), human CNS tumor cell lines (XF 498) and numan colon tumor cell lines (HCT 15) in vitro using a Sulforhodamine B assay. 3-Ethoxycarbonyl-1-(2-methoxyethyl)-2-methyl-1H-pyridino[2,3-f]indole-4,9-dione (5) showed excellent cytotoxicity against XF 498 and HCT 15. The ED_<50> values of 5 were 0.006 μg/ml against XF 498 and 0.073 μg/ml against HCT 15,while those of doxorubicin were 0.012 and 0.264 μg/ml, respectively. 1-Benzyl-3-ethoxycarbonyl-2-methyl-1H-pyridino[2,3-f]indole-4,9-dione (7) (ED_<50> value 0.065 μg/ml) was also significanty more cytotoxic against HCT 15 compared with doxorubicin.

• 公益社団法人日本薬学会の論文
• 2000-03-01

著者

• LEE Chong

  Pharmaceutical Screening Center, Korea Research Institute of Chemical Technology

• Park Hee-kyong

  Division Of Medicinal Chemistry College Of Pharmacy Ewha Womans University

• Lee Chong

  Pharmaceutical Screening Center Korea Research Institute Of Chemical Technology

• Yoo Hee-won

  Division Of Medicinal Chemistry College Of Pharmacy Ewha Womans University:(present Address)bukwang

• Suh Myung

  Division Of Medicinal Chemistry College Of Pharmacy Ewha Womans University

関連論文

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• Antiviral Effects of Sulfated Exopolysaccharide from the Marine Microalga Gyrodinium impudicum Strain KG03
• Cytotoxic Effects of Pyridino[2,3-f]indole-4,9-diones on Human Tumor Cell Lines

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