Phagocytic Activity of Ethyl Alcohol Fraction of Deer Antler in Murine Peritoneal Macrophage

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概要

• 論文の詳細を見る

• The mechanism of Phagocytic activity of the ethyl alcohol fraction of Cervus nippon (CN-E) was investigated in vivo. The administration of CN-E (100 mg/kg, p.o.) enhanced lucigenin chemiluminescence and the engulfment of fluorescein-conjugated E. coil particles in murine peritoneal macrophages. Phagocytic activity was suppressed by the treatment of S-nitrosoglutathione (GSNO) which is an exogenous nitric oxide donor depending on the concentration of dose. CN-E suppressed the production of nitric oxide and enhanced the concentration in [Ca^<2+>]_i. The enhancement in [Ca^<2+>]_i was diminished by the treatment of EGTA. These results indicate that CN-E enhances the phagocytic activity of murine peritoneal macrophage via a suppression of nitric oxide production and an increase in [Ca^<2+>]_i.

• 公益社団法人日本薬学会の論文
• 1999-09-15

著者

• JHON Gil-Ja

  Department of Chemistry and Division of Molecular Life Sciences, Ewha Womans University

• Suh Jeong-sook

  Department Of Chemistry Division Of Molecular Life Sciences And Center For Cell Signaling Research E

• Jhon Gil-ja

  Department Of Chemistry Division Of Molecular Life Sciences And Center For Cell Signaling Research E

• Eun Jae-soon

  Department Of Pharmacy Woosuk University

• SO June-No

  Department of Biotechnology Woosuk University

• SEO Jeong-Taeg

  Department of Oral Biology, Yonsei University College of Dentistry

関連論文

• Purification and Structural Determination of Hematopoietic Stem Cell-Stimulating Monoacetyldiglycerides from Cervus nippon (Deer Antler)
• Stimulatory Effects of Monoacetyldiglycerides on Hematopoiesis(Miscellaneous)
• Studies of the Chemical Structure of Gangliosides in Deer Antler, Cervus nippon
• Phagocytic Activity of Ethyl Alcohol Fraction of Deer Antler in Murine Peritoneal Macrophage

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