Expression of γ-Glutamylcysteine Synthetase mRNA in Regenerating Rat Liver
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概要
- 論文の詳細を見る
Changes in the level of GSH and γ-Glutamylcysteine Synthetase (γ-GCS) activity with time were determined during regeneration of rat liver after partial hepatectomy. The GSH level and γ-GCS activity increased in regenerating rat liver, reaching a maximum (2.1- and 1.5-fold that in sham-operated controls) on day 2,respectively. Furthermore, γ-GCS mRNA expression increased within 24 h and reached maximum on day 2. These results suggest that the increased GSH level in regenerating rat liver after partial hepatectomy is associated with the transcriptional activation of γ-GCS gene and the sequence elevation in γ-GCS activity.
- 公益社団法人日本薬学会の論文
- 1999-10-15
著者
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Tsuboi Seiji
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Okayama University
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Tsuboi Seiji
Department Of Biochemistry Faculty Of Pharmaceutical Science Okayama University
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- Expression of γ-Glutamylcysteine Synthetase mRNA in Regenerating Rat Liver