Screening of an Inhibitor of the Tetracycline Efflux Pump is a Tetracycline-Resistant Clinical-Isolate of Staphylococcus aureus 743
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概要
- 論文の詳細を見る
Clinically-isolated methicillin-resistant Staphylococcus aureus (MRSA) strain 743 exhibited resistance to tetracycline as judged from the active efflux of the drug. The efflux of tetracycline was inhibited by an uncoupler, carbonyl cyanide m-chlorophenylhydrazone (CCCP), and minocycline. Inhibitors of the efflux pump were examined in this strain to determine the cellular accumulation of tetracycline. Out of seven compounds examined, three caused a significant increase in the cellular concentration of tetracycline by inhibiting the efflux pump. Two of them seem to be energy inhibitors. Ro 07-3149 inhibited the efflux pump without affecting the energy state, and exhibited very low antibacterial activity but showed weak synergy with tetracycline.
- 公益社団法人日本薬学会の論文
- 1998-07-15
著者
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YAMAGUCHI Akihito
Department of Cell Membrane Biology, Institute of Scientific and Industrial Research, Osaka Universi
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Satoh Tomoko
Nippon Roche Research Center
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HIRATA Takahiro
Nippon Roche Research Center
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WAKATABE Rumi
Nippon Roche Research Center
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NIELSEN Joergen
Hoffman-La Roche Co., Ltd.,
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NIHIRA Shin-ichi
Nippon Roche Research Center
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Yamaguchi Akihito
Department Of Cell Membrane Biology Institute Of Scientific And Industrial Research Osaka University
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Yamaguchi Akihito
Department Of Integrated Human Sciences School Of Dentistry Health Sciences University Of Hokkaido
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Nielsen Joergen
Hoffman-la Roche Co. Ltd.
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Nihira S
Nippon Roche Research Center
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