In Vitro Screening for Antitumour Activity of Clinopodium vulgare L. (Lamiaceae) Extracts

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概要

• 論文の詳細を見る

• Aqueous extract of Clinopodium vulgare L. showed strong antitumour activity when tested in vitro on A2058 (human metastatic melanoma), HEp-2 (epidermoid carcinoma, larynx, human) and L5178Y (mouse lymphoma) cell lines-6 h after treatment disintegration of the nuclei and cell lysis started. Applied at a concentration of 80 μg/ml it reduced the cell survival to 1.0, 5.6 and 6.6%, respectively. The concentrations of aqueous extract inhibiting the growth of A2058, HEp-2 and L5178Y cells by 50% (IC_<50> values) were calculated to be 20, 10 and 17.8 μg/ml respectively. Two groups of active substances were detected: the first one, probably combining glycosides, influenced adhesion, while the second one caused massive cell vacuolisation. The chloroform extract, which contained ursolic acid and gentriacontan had also cytotoxic, however a little bit weaker effect. All changes observed were irreversible.

• 公益社団法人日本薬学会の論文
• 2002-04-01

著者

• Popov Nikola

  Cell Biology Lab. University Of Plovdiv

• DZHAMBAZOV Balik

  Section for Medical Inflammation Research, Department of Cell and Molecular Biology, Lund University

• DASKALOVA Sashka

  The Norman Borlaug Institute for Plant Science Research, De Montfort University

• MONTEVA Adriana

  Cell Biology Lab., University of Plovdiv

• Dzhambazov Balik

  Section For Medical Inflammation Research Department Of Cell And Molecular Biology Lund University

• Daskalova Sashka

  The Norman Borlaug Institute For Plant Science Research De Montfort University

• Monteva Adriana

  Cell Biology Lab. University Of Plovdiv

関連論文

• In Vitro Screening for Antitumour Activity of Clinopodium vulgare L. (Lamiaceae) Extracts

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