Lacunary-Substituted Undecatungstosilicates Sensitize Methicillin-Resistant Staphylococcus aureus to β-Lactams

概要

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Some Keggin-structural(hetero)polyoxotungstates with a lacunary hole, such as undecatungstosilicate([SiW_<11>O_<39>]^<8-> SiW_<11>), greatly sensitize methicillin-resistant Staphylococcus aureus(MRSA)to β-lactams. In this study, the effects of lacunary-substituted derivatives of SiW_<11> were tested to determine if the lacunary hole is required for the sensitizing effect. Initially, it was supposed that the hole functioned as a binding site that interacts with some bacterial components. However, most of the lacunary-substituted species had stronger effects than SiW_<11> indicating that the hole is not essential for the sensitizing effect. Undecatungsto(ferri)ferrosilicate ([SiW_<11>O_<39>Fe]^<6/5->)was the most potent compound tested, but undecatungstocobaltosilicate([SiW_<11>O_<39>Co]^<6->)gave better results according to the fractional inhibitory concentration index. Small lipophilic cations enhanced the sensitizing effect, but bulky cations inhibited it. This suggests that a charge interaction between the tungsten compounds and some unknown materials in the culture medium or bacterial cells plays an important role in the sensitizing effect.
公益社団法人日本薬学会の論文
2001-09-01