Determinations of Morin, Quercetin and Their Conjugate Metabolites in Serum

概要

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Morin and quercetin are isomeric antioxidant flavonols. High-performance liquid chromatographic methods were developed for the quantitation of morin and quercetin in serum. The method employed a Cosmosil RP-18 column, using acetonitrile/0.2% ο-phosphoric acid : 28/72 and 27/73(v/v)as mobile phases, with ethyl paraben and 6, 7-dimethoxycoumarin used as internal standards for morin and quercetin, respectively. Moreover, a strategy to stabilize morin/quercetin released from their glucuronides/sulfates in serum during hydrolysis was established. The present methods are applicable for determining morin, quercetin, and their glucuronides/sulfates in serum.
公益社団法人日本薬学会の論文
2001-08-01