2, 2-Diphenyl-1-picrylhydrazyl Hydrate, a Stable Radical, Is an α-Glucosidase Inhibitor

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概要

• 論文の詳細を見る

• Glycosidases play a pivotal role in processing of various glycoproteins and glycolipids. It is well known that glycosidases are also involved in a variety of degenerative metabolic disorders such as cancer and AIDS. In order to develop potent α-glucosidase inhibitors, we first screened 2, 2-Diphenyl-1-picrylhydrazyl hydarate was found to inhibit α- and β-glucosidases as well as α- and β-mandases. It was also shown to be a non-competitive inhibitor of yeast α-glucosidase with a K_i value of 1.1X10^<-6>_M. Taken together, we anticipate that 2, 2-diphenyl-1-picrylhydrazyl hydrate may be a potent inhibitor for some inburable metabolic disorders including AIDS.

• 公益社団法人日本薬学会の論文
• 2001-06-01

著者

• Kim N‐s

  Korea Research Institute Of Bioscience & Biotechnology

• Lee Sang-han

  Korea Research Institute Of Standards And Science

• Lee Sang-han

  Korea Research Institute Of Bioscience & Biotechnology

• Lee Dong-sun

  Biophysical Chemistry Laboratory The Institute Of Physical And Chemical Research Riken Harima Instit

• KIM Nam-Soon

  Korea Research Institute of Bioscience & Biotechnology

• Kim Nam-soon

  Sagami Chemical Research Center

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